|
KMID : 0364019960290111223
|
|
Korean Journal of Thoracic and Cardiovascular Surgery
1996 Volume.29 No. 11 p.1223 ~ p.1231
|
|
|
Expression Pattern of RB and p53 Proteins and its Correlation with Prognosis in Primary Lung Cancer
|
|
홍숙희
이상용/허혜경/최필조/우종수
|
|
|
Abstract
|
|
|
Immunohistochemical stains for RB and p53 tumor suppressor gene products were performed on 72 cases of resected primary lung cancer tissues to study the correlation between their expressions and the histologic types, the clinical stage, and the
survival
rate.
@ES The results were as follows.
@EN 1. The RB protein was altered or absent in 38 cases(52.8%), and the mutant p53 protein was detected in 35 cases(48.6%).
2. The incidences of RB and p53 protein expression were significantly different among the histologic types (p<0.05) but were not correlated with the clinical stages of lung cancer(p>0.05).
3. The two year survival rate of patients with alteration of both RB and p53 genes(RB-/p53+) was 22.4%, and that with no alteration of both genes (RB+/p53-) was 63.1%. This difference was statistically significant(p=0.01).
4. It was shown that alteration of RB protein greatly affects the prognosis of lung carcinoma by multivariate analysis of prognostic factors.
The presence or absence of RB and mutant p53 protein in tumor cells is closely related to the survival of primary lung cancer patients, and it is suggested that RB gene expression is an independent prognostic factor of primary lung cancer.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|